MARCO 抗体 (AA 420-431)
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Quick Overview for MARCO 抗体 (AA 420-431) (ABIN1108157)
抗原
See all MARCO 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 420-431
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特异性
- This antibody binds specifically to MARCO (recognizes domain V between residues 420 and 431), and has been shown to partially block ligand binding.
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无交叉反应
- 小鸡
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交叉反应 （详细）
- Species reactivity (tested):Human, Bovine.
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纯化方法
- Protein G Chromatography
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免疫原
- Human alveolar macrophages
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亚型
- IgG3
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anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 367-519) antibody
MARCO 适用: 大鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 421-520) antibodyMARCO 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 13-40) antibodyMARCO 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24662 unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 366-518) antibodyMARCO 适用: 小鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 370-419) antibodyMARCO 适用: 人, 小鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 71-120) antibodyMARCO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) antibodyMARCO 适用: 人 WB, IP, FACS, IF, IHC (fro) 宿主: 兔 Chimeric PLK1 unconjugated Recombinant Antibody
anti-Macrophage Receptor with Collagenous Structure (MARCO) (N-Term) antibodyMARCO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (C-Term) antibodyMARCO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA
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储存条件
- 4 °C
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储存方法
- Store undiluted at 2-8 °C.
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- MARCO (Macrophage Receptor with Collagenous Structure (MARCO))
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别名
- MARCO
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背景
- The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens.Synonyms: Scavenger Receptor, macrophage receptor with collagenous structure
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基因ID
- 8685
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NCBI登录号
- NP_006761
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UniProt
- Q9UEW3
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途径
- Activation of Innate immune Response
抗原
-
