Optimal working dilution should be determined by the investigator.
限制
仅限研究用
缓冲液
PBS, 0,03 % sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
抗原
Lipase A (LIPA)
(Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA))
别名
LIPA
背景
Lysosomal acid lipase (LAL), with 378-amino acid protein( 43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.Synonyms: Acid cholesteryl ester hydrolase, Cholesteryl esterase, EC=3.1.1.13, LAL, LIPA, Lipase A, Lysosomal acid lipase/cholesteryl ester hydrolase, Sterol esterase