EYA3 抗体 (Middle Region)
Quick Overview for EYA3 抗体 (Middle Region) (ABIN1107155)
抗原
See all EYA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- QSRKNMTSKN RGKRKADATS SQDSELERVF LWDLDETIII FHSLLTGSYA
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交叉反应 （详细）
- Species reactivity (expected):Mouse, Rat, DogSpecies reactivity (tested):Human
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纯化方法
- Purified using peptide immunoaffinity column
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免疫原
- The immunogen for anti-EYA3 antibody: synthetic peptide directed towards the middle region of human EYA3.
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anti-Eyes Absent Homolog 3 (EYA3) (AA 1-300) antibody
EYA3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Eyes Absent Homolog 3 (EYA3) antibodyEYA3 适用: 人, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Eyes Absent Homolog 3 (EYA3) (AA 277-326) antibodyEYA3 适用: 人, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eyes Absent Homolog 3 (EYA3) (AA 1-300) antibodyEYA3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Eyes Absent Homolog 3 (EYA3) (Middle Region) antibodyEYA3 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, Cow, 马, 绵羊, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Add 50 μL of distilled water to a final concentration of 1 mg/mL.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
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- EYA3 (Eyes Absent Homolog 3 (EYA3))
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别名
- EYA3
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背景
- EYA3 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. This protein promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. EYA3 coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity.Synonyms: Eyes absent homolog 3
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基因ID
- 2140
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NCBI登录号
- NP_001981
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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