Endomucin 抗体
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北京 101111
Quick Overview for Endomucin 抗体 (ABIN1107088)
抗原
See all Endomucin (EMCN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The monoclonal antibody V.7C7.1 recognizes endomucin, type I membrane protein of 248 amino acids (75 kDa) and shows no signicant homology to any known glycoprotein.
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无交叉反应
- 人
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交叉反应 （详细）
- Species reactivity (tested):Mouse.
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纯化方法
- Purified
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免疫原
- Mouse endomucin-IgG fusion protein
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亚型
- IgG2a
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anti-Endomucin (EMCN) antibody
EMCN 适用: 人, 小鼠, 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endomucin (EMCN) (AA 181-261) antibodyEMCN 适用: 人, 小鼠 ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endomucin (EMCN) (AA 21-120) antibodyEMCN 适用: 人, 小鼠 ELISA, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endomucin (EMCN) (AA 19-135) antibodyEMCN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endomucin (EMCN) antibodyEMCN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endomucin (EMCN) (AA 19-135) antibodyEMCN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Endomucin (EMCN) antibodyEMCN 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % Sodium Azide, 0.1 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 2-8 °C.
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- Endomucin (EMCN)
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别名
- Endomucin
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背景
- As a typical mucin-like glycoprotein, endomucin has a high content of serine and threonine residues, suggesting strong O-glycosylation, the sensitivity to O-sialoglycoprotein endopeptidase indicates that endomucin is also a sialomucin. Endomucin is an endothelial-specific sialomucin. It is a constitutively expressed endothelial cell surface protein that is found on all venules but is absent from high endothelial venule cells (HEV) of peripheral and mesenteric lymph nodes as well as Peyer's patches, the specialized site for most efficient lymphocyte trafficking. This could indicate an anti-adhesive function of endomucin, as demonstrated for other sialomucins. Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) is another cell adhesion molecule that contains a mucin-like domain and is expressed on HEV in Peyer's patches, mesenteric lymph nodes and on venules in intestinal lamina propria. In the HEV of mesenteric lymph nodes, the mucin-like domain of a subpopulation of MAdCAM-1 Molecules contains sulfated carbohydrate side chains that interact with L-selectin. The presence of three putative protein kinase C phosphorylation sites in the cytoplasmic tail of endomucin indicates that endomucin has the capacity to be a signaling molecule.Synonyms: EMCN, EMCN2, Endomucin-2, Gastric cancer antigen Ga34, MUC14, Mucin-14
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基因ID
- 59308
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NCBI登录号
- NP_001156994
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UniProt
- Q9R0H2
抗原
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