PI3 抗体
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北京 101111
Quick Overview for PI3 抗体 (ABIN1107080)
抗原
See all PI3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- TRAB2O recognises all known Trappins via the GQDPVK epitope. TRAB2O shows strong reaction with Human native full-length Elafin/SKALP and a weaker reaction with fully processed Elafin/SKALP (C-terminal 57 aa). For detection of fully processed Elafin/SKALP (C-terminal 57 aa) we advise to use AM26266PU-N. The antibody is cross reactive with Trappin family members of other species with GQDPVK epitope.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Protein G
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亚型
- IgG1
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anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 23-117) antibody
PI3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 1-117) antibodyPI3 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2G20 unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) antibodyPI3 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 1-117) antibodyPI3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G9 unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 41-117) antibodyPI3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 1-117) antibodyPI3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 36-85) antibodyPI3 适用: 人, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (N-Term) antibodyPI3 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % Sodium Azide, 0.1 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))
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别名
- Elafin / PI3
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背景
- Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria.Synonyms: ESI, Elastase-specific inhibitor, PI-3, Peptidase inhibitor 3, Protease inhibitor WAP3, SKALP, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, WAP3, WFDC14
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基因ID
- 5266
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NCBI登录号
- NP_002629
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UniProt
- P19957
抗原
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