RCAS1 抗体
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北京 101111
Quick Overview for RCAS1 抗体 (ABIN1107048)
抗原
See all RCAS1 (EBAG9) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognizes RCAS1.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Protein-L Sepharose
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免疫原
- Human uterine cervical adenocarcinoma cell
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亚型
- IgM
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- 100 μg IgG in 100 μLvolukme of PBS containing 50 % glycerol and 0.5 M NaCl, pH 7.2 No preservative is contained.
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储存液
- Azide free
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store (in aliquots) at -20 °C.
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- RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))
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别名
- EBAG9 / RCAS1
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背景
- RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a novel tumoreassociated antigen expressed in human uterine and ovarian carcinomas. The predicted amino acid sequence of RCAS1 (213 a.a.) possesses an N-terminal transmembrane region and a coiled-coil structure in the C-terminal portion, indicating that RCAS1 is a type II membrane protein able to form oligomers through the coiled-coil structure. RCAS1 revealed different expression pattern from the known tumore associated antigens such as, YH206, GA733, CA125, CEA and sialyl Le molecules in human tumore cell lines. Recent study indicated RCAS1 acts as a ligand for a putative receptor present on various human cells including T, B and NK cells. RCAS1 inhibited the in vitro growth of receptor-expressing cells and induced apoptosis. It was suggested that tumore cells might evade immune surveillance by expression of RCAS1.Synonyms: Cancer-associated surface antigen RCAS1, EB9, Estrogen receptor-binding fragment-associated gene 9 protein, PDAF, Receptor-binding cancer antigen expressed on SiSo cells
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基因ID
- 9166
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NCBI登录号
- NP_004206
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UniProt
- O00559
抗原
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