Dystroglycan 抗体
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- 抗原 See all Dystroglycan (DAG1) 抗体
- Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))
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适用
- 人, 小鼠, 大鼠, Cow, 兔
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Dystroglycan antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody is specific for a glycoepitope on brain bovine alpha-dystroglycan, which is absent on alpha-dystroglycan expressed in all other tissues.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat, rabbit, bovine
- 纯化方法
- Protein G purified
- 克隆位点
- 2238
- 亚型
- IgG2b
- Top Product
- Discover our top product DAG1 Primary Antibody
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anti-Dystroglycan 1 (DAG1) antibody
DAG1 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 718-747), (C-Term) antibodyDAG1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB33752 unconjugated
anti-Dystroglycan 1 (DAG1) (AA 28-406) antibodyDAG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 31-140) antibodyDAG1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A3 unconjugated
anti-Dystroglycan 1 (DAG1) (Internal Region) antibodyVerified DAG1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 726-744) antibodyDAG1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (C-Term) antibodyDAG1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 323-372) antibodyDAG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 猴, Bat, 小鸡, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 721-770) antibodyDAG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 猴, 豚鼠, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 654-749) antibodyDAG1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2 - 8 °C.
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- 抗原
- Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))
- 别名
- Dystroglycan (DAG1 产品)
- 别名
- LOC398500 antibody, dag1 antibody, MGC53537 antibody, 156DAG antibody, A3a antibody, AGRNR antibody, DAG antibody, MDDGC7 antibody, MDDGC9 antibody, DAG1 antibody, RAB7 antibody, dg antibody, a3a antibody, dag antibody, agrnr antibody, 156dag antibody, D9Wsu13e antibody, DG antibody, Dp427 antibody, Dp71 antibody, CG18250 antibody, CT41273 antibody, DmDG antibody, Dmel\\CG18250 antibody, atu antibody, dgn antibody, dys antibody, GB14967 antibody, APOJ antibody, CLI antibody, RATTRPM2B antibody, SGP-2 antibody, SGP2 antibody, SP-40 antibody, SP40 antibody, TRPM-2 antibody, TRPM2B antibody, Trpm2 antibody, Trpmb antibody, Ala-1 antibody, H9/25 antibody, Ly-27 antibody, Ly-6 antibody, Ly27 antibody, wu:fb83d06 antibody, wu:fi25f06 antibody, wu:fi37b08 antibody, zgc:109786 antibody, DystroGlycaN antibody, dystroglycan 1 L homeolog antibody, dystroglycan 1 antibody, dystroglycan 1 S homeolog antibody, Dystroglycan antibody, dystroglycan antibody, clusterin antibody, lymphocyte antigen 6 complex antibody, dgn-1 antibody, dag1.L antibody, dgn-2 antibody, dgn-3 antibody, DAG1 antibody, dag1.S antibody, Dag1 antibody, dag1 antibody, Dg antibody, LOC408826 antibody, Clu antibody, Ly6 antibody
- 背景
- Alpha-dystroglycan (alpha-DG), also known as dystrophin-associated glycoprotein, is a laminin-binding protein of ~156 kDa (including glyco-groups). Alpha-DG is a component of the dystroglycan complex, which is involved in early development, morphogenesis and in the pathogenesis of muscular dystrophies. Alpha- and beta-DG are encoded by a single gene and are derived from a precursor polypeptide by posttranslational cleavage. Beta-DG is an integral membrane protein, whereas alpha-DG is membrane-associated through its noncovalent interaction with the extracellular domain of beta-DG. The alpha- and beta-DGs provide important physical linkages between components of basement membranes and cytoplasmic proteins that bind to the actin cytoskeleton. Alpha-DG is a heavily glycosylated, mucin-like protein anchored on the extracellular surface of the myotube, where it may provide linkage between the sarcolemma and extracellular matrix (ECM). Alpha-DG is expressed in a variety of fetal and adult tissues. Tissue-specific glycosylation modifies the laminin specificity of alpha-DG. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alpha-DG has been shown to colocalize with laminin in skeletal and cardiac muscle and a number of other cells including peripheral nerve, astrocytes, Purkinje neurons and kidney epithelium. Laminin-10/11 was shown to bind preferentially to brain alpha-DG. In Duchenne muscular dystrophy, the expression of alpha-DG is dramatically reduced leading to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. In the central nervous system, dystroglycan functions as a dual receptor for agrin and laminin-2 for instance in the Schwann cell membrane. Furthermore, defects in dystroglycan are central to the pathogenesis of structural and functional brain abnormalities seen in congenital muscular dystrophies (CMD).Synonyms: DAG1, Dystrophin-associated glycoprotein 1
- 基因ID
- 281439
- NCBI登录号
- NP_776587
- UniProt
- O18738
- 途径
- Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
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