Dystroglycan 抗体
Quick Overview for Dystroglycan 抗体 (ABIN1107039)
抗原
See all Dystroglycan (DAG1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody is specific for a glycoepitope on brain bovine alpha-dystroglycan, which is absent on alpha-dystroglycan expressed in all other tissues.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat, rabbit, bovine
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纯化方法
- Protein G purified
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亚型
- IgG2b
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anti-Dystroglycan 1 (DAG1) antibody
DAG1 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 718-747), (C-Term) antibodyDAG1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB33752 unconjugated
anti-Dystroglycan 1 (DAG1) (AA 28-406) antibodyDAG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (Internal Region) antibodyVerified DAG1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 31-140) antibodyDAG1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A3 unconjugated
anti-Dystroglycan 1 (DAG1) (AA 726-744) antibodyDAG1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (C-Term) antibodyDAG1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 721-770) antibodyDAG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, Bat, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (AA 323-372) antibodyDAG1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, Bat, 小鸡, 猴, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Dystroglycan 1 (DAG1) (C-Term) antibodyDAG1 适用: 人 IHC, IHC (fro) 宿主: 小鼠 Monoclonal 43DAG1-8D5 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))
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别名
- Dystroglycan
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背景
- Alpha-dystroglycan (alpha-DG), also known as dystrophin-associated glycoprotein, is a laminin-binding protein of ~156 kDa (including glyco-groups). Alpha-DG is a component of the dystroglycan complex, which is involved in early development, morphogenesis and in the pathogenesis of muscular dystrophies. Alpha- and beta-DG are encoded by a single gene and are derived from a precursor polypeptide by posttranslational cleavage. Beta-DG is an integral membrane protein, whereas alpha-DG is membrane-associated through its noncovalent interaction with the extracellular domain of beta-DG. The alpha- and beta-DGs provide important physical linkages between components of basement membranes and cytoplasmic proteins that bind to the actin cytoskeleton. Alpha-DG is a heavily glycosylated, mucin-like protein anchored on the extracellular surface of the myotube, where it may provide linkage between the sarcolemma and extracellular matrix (ECM). Alpha-DG is expressed in a variety of fetal and adult tissues. Tissue-specific glycosylation modifies the laminin specificity of alpha-DG. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alpha-DG has been shown to colocalize with laminin in skeletal and cardiac muscle and a number of other cells including peripheral nerve, astrocytes, Purkinje neurons and kidney epithelium. Laminin-10/11 was shown to bind preferentially to brain alpha-DG. In Duchenne muscular dystrophy, the expression of alpha-DG is dramatically reduced leading to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. In the central nervous system, dystroglycan functions as a dual receptor for agrin and laminin-2 for instance in the Schwann cell membrane. Furthermore, defects in dystroglycan are central to the pathogenesis of structural and functional brain abnormalities seen in congenital muscular dystrophies (CMD).Synonyms: DAG1, Dystrophin-associated glycoprotein 1
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基因ID
- 281439
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NCBI登录号
- NP_776587
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UniProt
- O18738
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途径
- Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
抗原
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