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Deoxyuridine Triphosphatase (DUT) (Middle Region) 抗体

This anti- antibody is a 兔 多克隆 antibody detecting in WB, IHC (p) 和 IP. Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN1107021
发货至: 中国

Quick Overview for Deoxyuridine Triphosphatase (DUT) (Middle Region) 抗体 (ABIN1107021)

抗原

See all Deoxyuridine Triphosphatase (DUT) 抗体
Deoxyuridine Triphosphatase (DUT)

适用

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人, 大鼠, 小鼠

宿主

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克隆类型

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多克隆

标记

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非结合性

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
  • 抗原表位

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    Middle Region

    特异性

    This antibody detects DUT in the middle. No cross reactivity with other roteins.

    交叉反应 (详细)

    Species reactivity (tested):Human, mouse, rat

    纯化方法

    Immunogen affinity purified

    免疫原

    Synthetic peptide corresponding to a sequence mapping at the middle region of human dUTPase .Remarks: Sequence is identical to the related rat and ouse sequence.

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 溶解方式

    0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    缓冲液

    5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg himerosal, 0.05 mg NaN3

    储存液

    Sodium azide, Thimerosal (Merthiolate)

    注意事项

    This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    Deoxyuridine Triphosphatase (DUT)

    别名

    DUT

    背景

    Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is responsible for maintaining low ntracellular levels of dUTP, thus preventing the incorporation of dUTP into DNA. DUTPase ctivity/expression can be down-regulated using siRNA specifically targeted to dUTPase mRNA and UTPase plays a role in DNA nucleotide metabolism. This protein, present predominantly in the ytoplasm, contains 252 amino acids with a Mr of 26,704. It exhibits 35 % identity with the E. coli UTPase and 53 % identity with the Saccharomyces cerevisiae enzyme. The nuclear and mitochondrial orms of dUTPase are encoded by the same gene with isoform-specific transcripts arising through the se of alternative 5-prime exons. Human dUTPase exhibits 92 % identity with rat. Moreover, this nzyme has profound effects on the efficacy of agents that target thymidylate biosynthesis.Synonyms: Deoxyuridine 5'-triphosphate nucleotidohydrolase mitochondrial, dUTP pyrophosphatase, dUTPase

    基因ID

    1854

    NCBI登录号

    NP_001020419

    UniProt

    P33316
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