Complex II Subunit 70 KDa Fp (C-Term) 抗体
适用: 人, 小鼠, 大鼠
IHC (p), WB
宿主: 兔
Polyclonal
unconjugated
1 image
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- 抗原
- Complex II Subunit 70 KDa Fp
- 抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- 特异性
- This antibody detects Complex II subunit 70 kDa Fp (C-term). No cross reactivity with other proteins.
- 交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human, Rat. - 纯化方法
- Immunoaffinity Chromatography.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminal of Human SDHA .Remarks: Sequence is identical to the related Rat and Mouse sequence.
- 亚型
- IgG
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 溶解方式
- Restore with 1.2 % Sodium Acetate or Neutral PBS. If 0.5 mL of PBS is added the antibody concentration will be 0.1 mg/mL.
- 缓冲液
- 50 % Glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody after reconstitution at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- Complex II Subunit 70 KDa Fp
- 背景
- Complex II of the mitochondrial respiratory chain, also known as succinate dehydrogenase or succinate:ubiquinone oxidoreductase, consists of 4 nuclear-encoded polypeptides, these are the flavoprotein subunit (SDHA), the iron sulfur protein subunit (SDHB), and the integral membrane protein subunits SDHC and SDHD. SDHA is an acronym for succinate dehydrogenase complex subunit A. The succinate dehydrogenase (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). The SDHA subunit is connected to the SDHB subunit on the hydrophilic, catalytic end of the complex, and weighs 72.7 kDA. Mutations in the SDHA subunit have a distinct pathology from mutations in the SDHB/SDHC/SDHD subunits, it is the only subunit to never have shown tumor suppressor behaviour. Heterozygous carriers of an SDHA mutation do not develop paragangliomas as has been seen for mutations in the other subunits. This appears to be due to the expression of two similar SDHA genes (Types I and II) in the paraganglia system.Synonyms: Mitochondria Complex II (Succinat Dehydrogenase) 70 kD Fp subunit, SDH2, SDHA, SDHF, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
- 基因ID
- 6389
- NCBI登录号
- NP_004159
- UniProt
- P31040
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