This anti-Collagen Type V antibody is a 小鼠 单克隆 antibody detecting Collagen Type V in IHC (fro), EIA 和 RIA. Suitable for 人. This Primary Antibody has been cited in 1 publication.
The antibody reacts with native Human as well as heat denatured Human Collagen type V in RIA, ELISA and immunoblot assays. The antibody does not react with Collagen types I, II, III and IV. Human plasma proteins do not interfere with binding to collagen.
交叉反应 (详细)
Species reactivity (tested):Human.
纯化方法
PEG6000 precipitation + Sepharose 6B gel filtration
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
溶解方式
Restore with 1 mL sterile water. Add preservative if preferred.
储存条件
4 °C
储存方法
Store the antibody undiluted at 2-8 °C.
Rukosuev, Nanaev, Milovanov: "Participation of collagen types I, III, IV, V, and fibronectin in the formation of villi fibrosis in human term placenta." in: Acta histochemica, Vol. 89, Issue 1, pp. 11-6, (1991) (PubMed).
抗原
Collagen Type V (COL5)
(Collagen, Type V (COL5))
别名
Collagen Type V
背景
Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. Type V Collagen is a member of group I Collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V Collagen binds to DNA, heparan sulfate, Thrombospondin, Heparin, and Insulin. Collagen V is composed of several subunits as follows: trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Type V Collagen is closely related to type XI Collagen and it is possible that the Collagen chains of types V and XI constitute a single collagen type with tissue specific chain combinations. Mutations in this gene are associated with Ehlers Danlos syndrome, types I and II.Synonyms: COL5A1