CNF1 (AA 704-730) 抗体
The 小鼠 单克隆 anti-CNF1 antibody (Clone NG8) (ABIN1106727) specifically detects CNF1 in WB, Func, DB 和 EIA.
The antibody is reactive with E. coli samples.
产品编号 ABIN1106727
发货至:
中国
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Quick Overview for CNF1 (AA 704-730) 抗体 (ABIN1106727)
抗原
CNF1
适用
E. coli
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Functional Studies (Func), Dot Blot (DB), Enzyme Immunoassay (EIA)
克隆位点
NG8
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抗原表位
- AA 704-730
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特异性
- The Monoclonal antibody clone NG8 recognizes an epitope between amino acids 704 and 730 of the C-terminal enzymatic domain. NG8 specifically neutralizes CNF1 while lacking activity for CNF2.
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免疫原
- Synthetic peptide, corresponding to amino acids 704/730 of Escherichia coli CNF1
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- 0.1 % BSA
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- CNF1
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背景
- CNF1 and CNF2 belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho, however, CNF1 and the highly related CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin.Synonyms: Cytotoxic necrotizing factor 1
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分子量
- 115 kDa
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基因ID
- 3990770
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NCBI登录号
- YP_543855
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UniProt
- Q1R2U0
抗原
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