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CD43 抗体 (FITC)

SPN 适用: 人 FACS, IF 宿主: 小鼠 Monoclonal MT1 FITC
产品编号 ABIN1106375
发货至: 中国
  • 抗原 See all CD43 (SPN) 抗体
    CD43 (SPN) (Sialophorin (SPN))
    适用
    • 146
    • 9
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    宿主
    • 95
    • 61
    • 3
    小鼠
    克隆类型
    • 84
    • 74
    • 1
    单克隆
    标记
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    This CD43 antibody is conjugated to FITC
    应用范围
    • 103
    • 69
    • 62
    • 58
    • 39
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    • 5
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    Flow Cytometry (FACS), Immunofluorescence (IF)
    特异性
    Clone MT1, specific for CD43, produces mouse IgG1 immunoglobulins reactive with a 95-115 kDa highly sialated glycoprotein. Clone MT1 antibody is used to identify B cell lines and myeloma cells. It may be used in the diagnosis of chronic lymphocytic leukemias (CLL), as an alternative to CD5. The antigen detected by MT1 is the only marker expressed on neoplasms of the very early precursor cells. In immunohistochemistry it reacts with T cells, macrophages, myeloid cells and B cells (weak). It is used for the typing of lymphomas in paraffin sections [3-5].
    纯化方法
    Affinity chromatography
    克隆位点
    MT1
    亚型
    IgG1
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  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
  • 抗原
    CD43 (SPN) (Sialophorin (SPN))
    别名
    CD43 / Leukosialin (SPN 产品)
    别名
    CD43 antibody, GALGP antibody, GPL115 antibody, LSN antibody, A630014B01Rik antibody, Cd43 antibody, Galgp antibody, Ly-48 antibody, Ly48 antibody, Lsn antibody, Lsn1 antibody, gpL115 antibody, sialophorin antibody, SPN antibody, Spn antibody
    背景
    CD43 antigen is expressed on all T cells, NK cells, myeloid cells and monocytes as well as on CD5 positive mature B cells. It is also present on all immature hematopoietic cells in the bone marrow [1]. The antigen is deficient in patients with Wiskott-Aldrich syndrome. A soluble form of CD43 is present in human serum [2]. CD43 may function as an adhesion molecule via interaction with CD54 although this has not been definitely established. It may also inhibit leucocyte interactions with other cells [6]. The antigen is involved in the activation of T-cells, B cells, NK cells and monocytes [5]. The membrane proximal portion of the cytoplasmic domain mediates an association with the cytoskeleton [1].Synonyms: Galactoglycoprotein, Leukocyte sialoglycoprotein, SPN, Sialophorin
    基因ID
    6693
    NCBI登录号
    NP_001025459
    UniProt
    P16150
    途径
    Regulation of Leukocyte Mediated Immunity
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