F11R 抗体 (1st Extracellular Domain, Extracellular Domain)
Quick Overview for F11R 抗体 (1st Extracellular Domain, Extracellular Domain) (ABIN1106267)
抗原
See all F11R 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- 1st Extracellular Domain, Extracellular Domain
-
特异性
- The antibody reacts with the 12 kDa extracellular domain 1 of the human JAM-A protein.
-
无交叉反应
- 小鼠
-
交叉反应 （详细）
- Species reactivity (tested):Human.
-
纯化方法
- Protein A
-
免疫原
- Extracellular domain of full-length human JAM-A
-
亚型
- IgG
-
-
anti-F11 Receptor (F11R) (AA 1-299) antibody
F11R 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 2E3-1C8 unconjugated
anti-F11 Receptor (F11R) (AA 30-238) antibodyF11R 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (pTyr280) antibodyF11R 适用: 人 WB, ELISA, IF, FM 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (Internal Region) antibodyF11R 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 64-249) antibodyF11R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) antibodyF11R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 31-224) antibodyF11R 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) antibodyF11R 适用: 小鼠 FACS, IP, IHC (fro) 宿主: 大鼠 Monoclonal H202-106 unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.1 mg/mL
-
缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Store at 2 - 8 °C.
-
-
- F11R (F11 Receptor (F11R))
-
别名
- CD321 / JAM1
-
背景
- Together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAMs are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelial and epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all other JAMs, JAM-A play an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration. Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A/Fc fusion proteins. Homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the b2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to actively guide leukocytes during transmigration. Several studies imply a role of JAM-A in the initiation of atherosclerosis, since JAM-A is upregulated on early atherosclerotic endothelium and adhesion of activated platelets on activated endothelium is mediated by homophilic interactions of JAM-A.Synonyms: F11R, JAM-A, JCAM, Junctional adhesion molecule 1, Junctional adhesion molecule A, PAM1, Platelet F11 receptor, Platelet adhesion molecule 1
-
基因ID
- 50848
-
NCBI登录号
- NP_058642
-
UniProt
- Q9Y624
-
途径
- Cell-Cell Junction Organization
抗原
-
