F11R 抗体
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- 抗原 See all F11R 抗体
- F11R (F11 Receptor (F11R))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This F11R antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Functional Studies (Func)
- 特异性
- The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) or JAM-1.
- 交叉反应 （详细）
- Species reactivity (tested):Human
- 纯化方法
- Protein G
- 免疫原
- Human platelet membranes
- 克隆位点
- M-Ab-F11
- 亚型
- IgG1
- Top Product
- Discover our top product F11R Primary Antibody
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anti-F11 Receptor (F11R) (AA 1-299) antibody
F11R 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 2E3-1C8 unconjugated
anti-F11 Receptor (F11R) (AA 30-238) antibodyF11R 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (Internal Region) antibodyF11R 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 64-249) antibodyF11R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) antibodyF11R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 31-224) antibodyF11R 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-F11 Receptor (F11R) (C-Term) antibodyF11R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 51-150) antibodyF11R 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.1 % bovine serum albumin
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
- 有效期
- 6 months
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- 抗原
- F11R (F11 Receptor (F11R))
- 别名
- CD321 / JAM1 (F11R 产品)
- 别名
- CD321 antibody, JAM antibody, JAM1 antibody, JAMA antibody, JCAM antibody, KAT antibody, PAM-1 antibody, 9130004G24 antibody, AA638916 antibody, ESTM33 antibody, JAM-1 antibody, JAM-A antibody, Jcam antibody, Jcam1 antibody, Ly106 antibody, Jam1 antibody, F11 receptor antibody, F11R antibody, F11r antibody
- 背景
- JAM-A is a surface glycoprotein duplex (32 and 35 kDa) belongingto the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interactions. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulin and occludin. Moreover, JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading. In the platelet, JAM-A is a membrane protein involved in 2 distinct processes initiated on the platelet surface. Namely, antibody-induced platelet aggregation and secretion both dependent on FcgammaRII and GPIIb/IIIa integrin, a process that may be involved in pathophysiological processes associated with certain thrombocytopenias and secondly, antibody mediated platelet adhesion independent from FcgammaRII or fibrinogen receptor that appears to play a role in physiological processes associated with platelet adhesion and aggregation. A physiological role for the JAM-A protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the JAM-A was revealed by demonstrating the presence of JAM-A antibodies in patients with thrombocytopenia. Adhesion of platelets through JAM-A resulted in events characteristic of the action of cell adhesion molecules. Recent data suggests a role for JAM-A in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes.Synonyms: F11R, JAM-A, JCAM, Junctional adhesion molecule 1, Junctional adhesion molecule A, PAM1, Platelet F11 receptor, Platelet adhesion molecule 1
- 基因ID
- 50848
- NCBI登录号
- NP_058642
- UniProt
- Q9Y624
- 途径
- Cell-Cell Junction Organization
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