CD180 抗体 (Biotin)
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- 抗原 See all CD180 抗体
- CD180 (CD180 Molecule (CD180))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CD180 antibody is conjugated to Biotin
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应用范围
- Flow Cytometry (FACS)
- 交叉反应 (详细)
- Species reactivity (tested):Mouse
- 纯化方法
- Protein G
- 克隆位点
- RP-14
- 亚型
- IgG2a
- Top Product
- Discover our top product CD180 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
- 有效期
- 6 months
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- 抗原
- CD180 (CD180 Molecule (CD180))
- 别名
- CD180 / RP105 (CD180 产品)
- 背景
- Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-riche repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105.Synonyms: LY64, Lymphocyte antigen 64, Radioprotective 105 kDa protein
- 基因ID
- 10090
- UniProt
- Q62192
- 途径
- Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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