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CD13 抗体

ANPEP 适用: 小鼠 FACS, IHC (fro), IHC (p) 宿主: 大鼠 Monoclonal ER-BMDM1 unconjugated
产品编号 ABIN1105835
发货至: 中国
  • 抗原 See all CD13 (ANPEP) 抗体
    CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
    适用
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    小鼠
    宿主
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    大鼠
    克隆类型
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    单克隆
    标记
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    This CD13 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    The monoclonal antibody ER-BMDM1 is directed against a 160- kDa cell membrane-associated antigen with aminopeptidase N activity. The antigen recognized by the mocnoclonal antibody ER-BMDM1 is present on various Mouse macrophage and dendritic cell subpopulations as well as on microvillous epithelia. The ER-BMDM1 antigen is expressed at increasing levels upon maturation of macrophages. Therefore the monoclonal antibody ER-BMDM1 is a useful marker for the identification of Aminopeptidase N positive macrophages and dendritic cells in Mouse, the expression of the ER-BMDM1 antigen arises after the monocytic stage of differentation: bone marrow cells and peripheral blood monocytes are ER-BMDM1 negative, whereas mature macrophages express the ER-BMDM1 antigen. A subpopulation of dendrocytes and their in vitro equivalents, the dendritic cells, are also ER-BMDM1 positive.
    交叉反应 (详细)
    Species reactivity (tested):Mouse.
    纯化方法
    Protein G Chromatography
    克隆位点
    ER-BMDM1
    亚型
    IgG2a
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    Discover our top product ANPEP Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, 0.02 % Sodium Azide, 0.1 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
    别名
    CD13 (ANPEP 产品)
    背景
    Aminopeptidase N (APN) is also known as Alanyl Aminopeptidase (ANPEP), CD13 antigen or membrane protein p161. The protein consists of a short cyplasmic tail, a transmembrane region, a Ser/Thr region, and a zinc metalloproteinase domain. Widely expressed in many cells, tissues, and species, aminopeptidase N cleaves the N-terminal amino acids from bioactive peptides, leading to their inactivation or degradation. It has putative involvement in several biological processes including antigen processing and presentation, cell adhesion, tumor invasion and metastasis and neurotransmitter degradation.Synonyms: ANPEP, APN, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, PEPN, gp150
    基因ID
    16790
    NCBI登录号
    NP_032512
    UniProt
    P97449
    途径
    Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
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