BPI 抗体
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北京 101111
Quick Overview for BPI 抗体 (ABIN1105557)
抗原
See all BPI 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The polyclonal antibody reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). It recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein A
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亚型
- IgG
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anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 320-457) antibody
BPI 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 140-250) antibodyBPI 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 149-362) antibodyBPI 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (Internal Region) antibodyBPI 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 293-324) antibodyBPI 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB17726 unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 301-331), (Middle Region) antibodyBPI 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 248-487) antibodyBPI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (Internal Region) antibodyVerified BPI 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) antibodyBPI 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 320-452) antibodyBPI 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- BPI (Bactericidal/Permeability Increasing Protein (BPI))
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别名
- BPI
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背景
- The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.Synonyms: Bactericidal permeability-increasing protein, CAP57
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基因ID
- 671
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NCBI登录号
- NP_001716
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UniProt
- P17213
抗原
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