BPI 抗体
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北京 101111
Quick Overview for BPI 抗体 (ABIN1105556)
抗原
See all BPI 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein G
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亚型
- IgG1
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anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 320-457) antibody
BPI 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 140-250) antibodyBPI 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 149-362) antibodyBPI 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (Internal Region) antibodyBPI 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 293-324) antibodyBPI 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB17726 unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 301-331), (Middle Region) antibodyBPI 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 248-487) antibodyBPI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (Internal Region) antibodyVerified BPI 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) antibodyBPI 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Bactericidal/Permeability Increasing Protein (BPI) (AA 320-452) antibodyBPI 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- BPI (Bactericidal/Permeability Increasing Protein (BPI))
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别名
- BPI
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背景
- The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.Synonyms: Bactericidal permeability-increasing protein, CAP57
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基因ID
- 9606
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UniProt
- P17213
抗原
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