SLPI 抗体 (Biotin)
Quick Overview for SLPI 抗体 (Biotin) (ABIN1105385)
抗原
See all SLPI 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein G
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免疫原
- SLPI purified from sputum
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亚型
- IgG1
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anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 20-131) antibody
SLPI 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 26-132) antibodySLPI 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 33-132) antibodySLPI 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C6 unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) antibodySLPI 适用: 人 WB, ELISA, IHC, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal 31 unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) antibodySLPI 适用: 人 WB, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 31 unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (N-Term) antibodySLPI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (Center) antibodySLPI 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 11-60) antibodySLPI 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 1-132) antibodySLPI 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 26-132) antibodySLPI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
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别名
- Antileukoproteinase (ALP)
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背景
- SLPI was identified as an alarm reactant and expression is induced by inflammatory factors like LPS, IL1β, TNFα and neutrophils elastase. SLPI is a relatively small basic antiprotease of 11.7 kDa and is a cationic non-glycosylated protein consisting of 107amino acids. SLPI has a high affinity for the neutrophil serine proteinases, elastase and cathepsin G. Orthologues of SLPI have been found in mice, rate, pigs and sheep. It consists of two highly similar WAP ('whey acid protein')/four-disulphide core domains. SLPI contain 16 cysteine residues which assemble into eight disulphide bridges (four in each WAP domain). SLPI is constitutively expressed at many mucosal surfaces and is produced by a variety of epithelial cells, including respiratory, intestinal and amniotic epithelia. Expression is also detected in mast cells, neutrophils and macrophages. Expression of SLPI gene is significantly increased by progesterone and by the pro-inflammatory cytokines TNF-α and IL1-β. Although SLPI has been shown to inhibit a spectrum of proteases (including HNE, cathepsin G, trypsin, chymotrypsin and chymase), its main action in this regard is likely to be the inhibition of elastase, as indicated by its low dissociation constant and favourable kinetics of inhibition for this enzyme. SLPI has been described in several body fluids like seminal fluid, bronchial fluids, cervical fluids and saliva. It has been found to be antibacterial, antifungal, anti-retroviral, and to have an important role in mucosal defence. SLPI might also facilitate tumor spread, contributing to wound healing, is elevated in sepsis and levels seem to correlate with oral candidiasis in HIV-1 positive patients.Synonyms: BLPI, HUSI-1, Mucus proteinase inhibitor, Protease inhibitor WAP4, SLPI, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, WAP4, WFDC4
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UniProt
- P03973
抗原
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