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SLPI 抗体

SLPI 适用: 人 WB, IP, IHC (p), IHC (fro), EIA 宿主: 小鼠 Monoclonal 31 unconjugated
产品编号 ABIN1105383
发货至: 中国
  • 抗原 See all SLPI 抗体
    SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
    适用
    • 47
    • 10
    宿主
    • 39
    • 11
    • 3
    小鼠
    克隆类型
    • 43
    • 10
    单克隆
    标记
    • 23
    • 11
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLPI antibody is un-conjugated
    应用范围
    • 42
    • 24
    • 16
    • 11
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Protein G
    免疫原
    SLPI purified from sputum
    克隆位点
    31
    亚型
    IgG1
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    Discover our top product SLPI Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2 - 8 °C.
  • 抗原
    SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
    别名
    Antileukoproteinase (ALP) (SLPI 产品)
    别名
    ALK1 antibody, ALP antibody, BLPI antibody, HUSI antibody, HUSI-I antibody, MPI antibody, WAP4 antibody, WFDC4 antibody, MATN4 antibody, SLPI antibody, ckpi antibody, secretory leukocyte peptidase inhibitor antibody, antileukoproteinase antibody, SLPI antibody, Slpi antibody, LOC102174044 antibody
    背景
    SLPI was identified as an alarm reactant and expression is induced by inflammatory factors like LPS, IL1β, TNFα and neutrophils elastase. SLPI is a relatively small basic antiprotease of 11.7 kDa and is a cationic non-glycosylated protein consisting of 107amino acids. SLPI has a high affinity for the neutrophil serine proteinases, elastase and cathepsin G. Orthologues of SLPI have been found in mice, rate, pigs and sheep. It consists of two highly similar WAP ('whey acid protein')/four-disulphide core domains. SLPI contain 16 cysteine residues which assemble into eight disulphide bridges (four in each WAP domain). SLPI is constitutively expressed at many mucosal surfaces and is produced by a variety of epithelial cells, including respiratory, intestinal and amniotic epithelia. Expression is also detected in mast cells, neutrophils and macrophages. Expression of SLPI gene is significantly increased by progesterone and by the pro-inflammatory cytokines TNF-α and IL1-β. Although SLPI has been shown to inhibit a spectrum of proteases (including HNE, cathepsin G, trypsin, chymotrypsin and chymase), its main action in this regard is likely to be the inhibition of elastase, as indicated by its low dissociation constant and favourable kinetics of inhibition for this enzyme. SLPI has been described in several body fluids like seminal fluid, bronchial fluids, cervical fluids and saliva. It has been found to be antibacterial, antifungal, anti-retroviral, and to have an important role in mucosal defence. SLPI might also facilitate tumor spread, contributing to wound healing, is elevated in sepsis and levels seem to correlate with oral candidiasis in HIV-1 positive patients.Synonyms: BLPI, HUSI-1, Mucus proteinase inhibitor, Protease inhibitor WAP4, SLPI, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, WAP4, WFDC4
    UniProt
    P03973
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