SNCA 抗体 (AA 1-140)
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Quick Overview for SNCA 抗体 (AA 1-140) (ABIN1105339)
抗原
See all SNCA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-140
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特异性
- This antibody recognizes the recombinant α-synuclein.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Protein G affinity purified
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免疫原
- Recombinant human alpha-synuclein (1-140 aa) expressed in E. coli.
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Double distillated water is recommended to adjust the final concentration to 1.00 mg/mL.
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缓冲液
- 0.01 M PBS pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.
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- SNCA (Synuclein, alpha (SNCA))
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别名
- alpha-Synuclein / SNCA
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背景
- Alpha-Synuclein belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. Alpha-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble Aβ into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and is also observed in senile plaques of Alzheimer's disease patients. Human α-synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
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基因ID
- 6622
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NCBI登录号
- NP_000336
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UniProt
- P37840
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途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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