ALPL 抗体
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北京 101111
Quick Overview for ALPL 抗体 (ABIN1105293)
抗原
See all ALPL 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes Human Alkaline phosphatase / ALPL. Other species not tested.
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纯化方法
- Purified
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, 0.05 % Sodium Azide, 0.5 % protein stabilizer
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
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别名
- Alkaline Phosphatase / ALPL
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背景
- There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.Synonyms: AP-TNAP, Alkaline phosphatase, Alkaline phosphatase liver/bone/kidney isozyme, TNSALP, tissue-nonspecific isozyme
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分子量
- 57.3 kDa
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基因ID
- 249
抗原
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