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ACLY 抗体 (AA 306-502)

This anti-ACLY antibody is a 小鼠 单克隆 antibody detecting ACLY in WB, ELISA, IHC, FACS 和 ICC. Suitable for 人, 小鼠, 大鼠 和 猴. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN1098143
发货至: 中国

Quick Overview for ACLY 抗体 (AA 306-502) (ABIN1098143)

抗原

See all ACLY 抗体
ACLY (ATP Citrate Lyase (ACLY))

适用

  • 96
  • 34
  • 32
  • 8
  • 6
  • 6
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
人, 小鼠, 大鼠, 猴

宿主

  • 86
  • 13
小鼠

克隆类型

  • 72
  • 27
单克隆

标记

  • 53
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This ACLY antibody is un-conjugated

应用范围

  • 81
  • 36
  • 27
  • 26
  • 19
  • 19
  • 17
  • 11
  • 11
  • 6
  • 6
  • 3
  • 3
  • 2
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

克隆位点

5F8D11
  • 抗原表位

    • 19
    • 15
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 306-502

    原理

    ACLY Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human ACLY (AA: 306-502 ) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Chu, Lin, Hendel, Kulpa, Brownsey, Johnson: "ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32606-15, (2010) (PubMed).

    Beckner, Fellows-Mayle, Zhang, Agostino, Kant, Day, Pollack: "Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 10, pp. 2282-95, (2010) (PubMed).

  • 抗原

    ACLY (ATP Citrate Lyase (ACLY))

    别名

    ACLY

    背景

    ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.


    分子量

    125 kDa

    基因ID

    47

    UniProt

    P53396

    途径

    Warburg Effect
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