CSNK2A2 抗体 (AA 194-350)
Quick Overview for CSNK2A2 抗体 (AA 194-350) (ABIN1098114)
抗原
See all CSNK2A2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 194-350
-
原理
- CSNK2A2 Antibody
-
纯化方法
- Ascitic fluid
-
免疫原
- Purified recombinant fragment of human CSNK2A2 (AA: 194-350) expressed in E. Coli.
-
亚型
- IgG1
-
-
-
-
应用备注
-
ELISA: 1/10000
FCM: 1/200 - 1/400
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
-
-
Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression." in: European journal of immunology, Vol. 39, Issue 1, pp. 267-79, (2009) (PubMed).
: "KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit." in: Cellular and molecular life sciences : CMLS, Vol. 66, Issue 2, pp. 339-49, (2009) (PubMed).
: "
-
Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression." in: European journal of immunology, Vol. 39, Issue 1, pp. 267-79, (2009) (PubMed).
-
- CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))
-
别名
- CSNK2A2
-
背景
- Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
-
分子量
- 41.2 kDa
-
基因ID
- 1459
-
UniProt
- P19784
-
途径
- SARS-CoV-2 Protein Interactome
抗原
-