Rec.Pr.Thyrosin Phosphate (RPTP) 抗体
This anti- antibody is a 小鼠 单克隆 antibody detecting in FACS, IF, IP 和 WB. Suitable for 人, Pig 和 大鼠. This Primary Antibody has been cited in 1 publication.
(1 reference)Quick Overview for Rec.Pr.Thyrosin Phosphate (RPTP) 抗体 (ABIN1042487)
抗原
Rec.Pr.Thyrosin Phosphate (RPTP)
适用
人, Pig, 大鼠
宿主
小鼠
克隆类型
单克隆
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
克隆位点
3D7
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特异性
- Monoclonal antibodies 3G4 and 3D7 have been directed against the extracellular domain of RPTPµ.
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产品特性
- Cell adhesion
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纯化方法
- Purified
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亚型
- IgG2a
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应用备注
- 3D7 is useful for western blot, immunofluorescence, immunoprecipitation and flow cytometry. Optimal antibody dilution should be determined by titration.
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说明
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3D7 is a mouse monoclonal IgG2a antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the human RPTPµ molecule (aa 1-742), fused COOH terminally to GST.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.09% sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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: "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)." in: The Journal of biological chemistry, Vol. 275, Issue 15, pp. 11264-9, (2000) (PubMed).
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: "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)." in: The Journal of biological chemistry, Vol. 275, Issue 15, pp. 11264-9, (2000) (PubMed).
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- Rec.Pr.Thyrosin Phosphate (RPTP)
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背景
- Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substrates. RPTPµ is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPµ consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPµ is catalytically active, whereas its second (C-terminal) domain is inactive. RPTPµ is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
抗原
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