KCC2 抗体 (AA 932-1043)
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- 抗原 See all KCC2 (SLC12A5) 抗体
- KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))
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抗原表位
- AA 932-1043
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适用
- 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This KCC2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Detects ~140 kDa.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Protein G Purified
- 免疫原
- Fusion protein amino acids 932-1043 corresponding to rat KCC2
- 克隆位点
- S1-12
- 亚型
- IgG2a
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anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) antibody
SLC12A5 适用: 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (HRP)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 HRP
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (FITC)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 FITC
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (Biotin)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 Biotin
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (PE)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 PE
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (APC)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 APC
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (PerCP)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 PerCP
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (Atto 488)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 Atto 488
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (Atto 594)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 Atto 594
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) (AA 932-1043) antibody (Atto 390)SLC12A5 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal S1-12 Atto 390
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- 应用备注
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- WB (1:1000)
- IHC (1:300)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- 说明
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1 μg/ml of ABIN1027708 was sufficient for detection of KCC2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))
- 别名
- KCC2 (SLC12A5 产品)
- 别名
- Kcc2 antibody, KCC2 antibody, mKIAA1176 antibody, solute carrier family 12 member 5 antibody, solute carrier family 12, member 5 antibody, SLC12A5 antibody, Slc12a5 antibody
- 背景
- KCC2 is a member of the cation-chloride cotransporter gene family (1). It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain (2, 3). KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord (4). Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.
- 基因ID
- 171373
- NCBI登录号
- NP_599190
- UniProt
- Q63633
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