N epsilon Hexanoyl-Keyhole Limpet Hemocyanin (HEL-KLH) 抗体
适用: Keyhole Limpet
IHC, ELISA
宿主: Human, 大鼠
Monoclonal
5F12
unconjugated
(6 references)-
- 抗原
- N epsilon Hexanoyl-Keyhole Limpet Hemocyanin (HEL-KLH)
- 适用
- Keyhole Limpet
- 宿主
- Human, 大鼠
- 克隆类型
- 单克隆
- 应用范围
- Immunohistochemistry (IHC), ELISA
- 特异性
- Specific to Hexanoyl-Lys adducts.
- 克隆位点
- 5F12
- 亚型
- IgG1 kappa
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- 应用备注
- Recommended antibody concentration is 2 µg/mL on paraformaldehyde fixed tissue.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Containing 10mM PBS(pH7.4), 5% sucrose, 1% BSA and 0.05% Procline 950. 100 µg/mL of IgG.
- 储存液
- ProClin
- 储存条件
- -20 °C
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: "Expressions of lipid oxidation markers, N(ε)-hexanoyl lysine and acrolein in cisplatin-induced nephrotoxicity in rats." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 73, Issue 6, pp. 821-6, (2011) (PubMed).
: "Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion." in: Journal of clinical biochemistry and nutrition, Vol. 47, Issue 2, pp. 130-7, (2010) (PubMed).
: "Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease." in: Molecular vision, Vol. 16, pp. 2465-75, (2010) (PubMed).
: "Immunohistochemical detection of oxidative stress biomarkers, dityrosine and N(epsilon)-(hexanoyl)lysine, and C-reactive protein in rabbit atherosclerotic lesions." in: Journal of atherosclerosis and thrombosis, Vol. 15, Issue 4, pp. 185-92, (2008) (PubMed).
: "Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress." in: Stroke; a journal of cerebral circulation, Vol. 36, Issue 3, pp. 670-2, (2005) (PubMed).
: "Increase in oxidative stress in kidneys of diabetic Akita mice." in: Bioscience, biotechnology, and biochemistry, Vol. 66, Issue 4, pp. 869-72, (2002) (PubMed).
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: "Expressions of lipid oxidation markers, N(ε)-hexanoyl lysine and acrolein in cisplatin-induced nephrotoxicity in rats." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 73, Issue 6, pp. 821-6, (2011) (PubMed).
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- 抗原
- N epsilon Hexanoyl-Keyhole Limpet Hemocyanin (HEL-KLH)
- 背景
- Oxidative damage of lipids caused by reactive oxygen species (ROS) play an important role in some diseases, lesion of cell functions and aging. Aldehydes such as malondi-aldehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) have been reported as one of the advanced lipid peroxidation products. But recently in the earlier stage of lipid peroxidation, 13-hydroperoxyoctadecanoic acid (13-HPODE) is found to be covalently bound to proteins1). Hexanoyl-Lysine adduct (HEL) is a novel lipid hydroperoxide-modified lysine residues. HEL is formed by oxidative modification by oxidized omega-6 fatty acids such as linoleic acid or arachidonic acid. This monoclonal antibody (clone 5H4)is spesific for proteins and peptides containing HEL. Suitable for HEL detection by immunohistochemistry and western blotting.
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