Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Latest Publications for our Antizyme Inhibitor 1 抗体
Greenwood, Greenwood, Paton, Murphy: "Control of Polyamine Biosynthesis by Antizyme Inhibitor 1 Is Important for Transcriptional Regulation of Arginine Vasopressin in the Male Rat Hypothalamus." in: Endocrinology, Vol. 156, Issue 8, pp. 2905-17, (2015) (PubMed).
Mangold, Hayakawa, Coughlin, Münger, Zetter: "Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification." in: Oncogene, Vol. 27, Issue 5, pp. 604-13, (2008) (PubMed).
Kim, Mangold, Waghorne, Mobascher, Shantz, Banyard, Zetter: "Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism." in: Journal of cell science, Vol. 119, Issue Pt 12, pp. 2583-91, (2006) (PubMed).