This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
ANXA2
宿主: Cynomolgus
宿主: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Sun, Gao, Cai, Wang, Qu, He, Liu, Zhang, Lin, Ma, Yang, Qian, Zhao: "Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma." in: Carcinogenesis, Vol. 34, Issue 3, pp. 595-604, (2013) (PubMed).
Deng, Lei, Zhang, Zhang, Zheng, Zhang, Pan, Wang, Tian, Shen, Zhao, Lundberg, Liu, Papasian, Deng: "Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans." in: Molecular & cellular proteomics : MCP, Vol. 10, Issue 11, pp. M111.011700, (2011) (PubMed).
Yung, Cheung, Zhang, Chan: "Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 11, pp. 1912-27, (2010) (PubMed).
Bhattacharjee, Ahamed, Pawlinski, Liu, Mackman, Ruf, Edgington: "Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1." in: Circulation research, Vol. 102, Issue 4, pp. 457-64, (2008) (PubMed).