The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008].
Umeda-Yano, Hashimoto, Yamamori, Okada, Yasuda, Ohi, Fukumoto, Ito, Takeda: "The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia." in: Schizophrenia research, (2013) (PubMed).