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eEF2 may be activated in a positive feedback cycle through inactivation of eEF2K (显示 EEF2K 蛋白) via the PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白)/mTOR (显示 FRAP1 蛋白) pathway.
the direct interaction of AKT2 (显示 AKT2 蛋白) and EF2 was found to be dynamically regulated in embryonic rat cardiomyocytes
These results suggest that binding of eEF2 to the ribosome alters its conformation, resulting in a weakened affinity of eIF5A (显示 EIF5 蛋白) and impairment of this interplay compromises cell growth due to translation elongation defects.
nuclear localization of active eEF-2 depends upon its interaction with p53 (显示 TP53 蛋白), as cells lacking p53 (显示 TP53 蛋白) contain less active eEF-2 in the nuclear compartment
High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer.
Results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth.
The expression levels of three putative HA-regulated proteins (TALDO, ANXA1 (显示 ANXA1 蛋白) and EF2) in control, H2O2-, HA- and HA/H2O2-treated OA chondrocytes were verified by Western blotting and the results indeed support the notion that HA acts in anti-oxidation
Data indicate that the accumulation of the cleaved C-terminal small fragment of eukaryotic elongation factor 2 (eEF2) in the nucleus, and C-terminal Src kinase (Csk (显示 CSK 蛋白)) could enhance the proteolytic cleavage of eEF2.
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
A single amino acid substitution in eukaryotic elongation factor 2 co-segregates with the disease phenotype of spinocerebellar ataxia 26.
Myostatin (显示 MSTN 蛋白) inhibits eEF2K (显示 EEF2K 蛋白)-eEF2 by regulating AMPK (显示 PRKAA1 蛋白) to suppress protein synthesis.
IL-6 (显示 IL6 蛋白) induces the activation of the Stat3 (显示 STAT3 蛋白) signaling and promotes the downmodulation of the p90RSK (显示 RPS6KA1 蛋白)/eEF2 and mTOR (显示 FRAP1 蛋白)/p70S6K (显示 RPS6KB1 蛋白) axes, while it does not affect the activation of AKT (显示 AKT1 蛋白).
AMPKalpha2 (显示 PRKAA2 蛋白) controls cardiac p70S6K (显示 RPS6KB1 蛋白) under normoxia and regulates eEF-2 but not the mTOR (显示 FRAP1 蛋白)-p70S6K (显示 RPS6KB1 蛋白) pathway during ischemia.
The MKK3 (显示 MAP2K3 蛋白)/6-p38gamma (显示 MAPK12 蛋白)/delta pathway mediated an inhibitory phosphorylation of eukaryotic elongation factor 2 (eEF2) kinase, which in turn promoted eEF2 activation (dephosphorylation) and subsequent TNF-alpha (显示 TNF 蛋白) elongation.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
induced by basic fibroblast growth factor (显示 FGF2 蛋白) via mitogen-activated protein kinase (显示 MAPK1 蛋白)
eEF-2 is activated by both lithium and GSK-3, whereas, lithium treatment and inhibition of GSK-3 have opposing effects on eEF-2.
eEF-2 phosphorylation has a role in protein synthesis for memory consolidation
A mouse that was mutant for the gene, Dph4 (显示 DNAJC24 蛋白), was identified.
Eukaryotic elongation factor-2 (eEF2) may be a limiting factor in milk protein (显示 CSN2 蛋白) synthesis (Review)
EF-2 is a developmentally regulated gene and might play important roles during the early development of zebrafish embryos.
Whole mount in situ hybridization on zebrafish embryos shows that the transcripts of EF-2 gene are detected during the early development of zebrafish embryo and constantly change from 5-somite stage to protruding-mouth stage.
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
elongation factor 2
, polypeptidyl-tRNA translocase
, elongation factor-2
, eukaryotic translation elongation factor 2
, elongation factor 2-like
, eukaryotic translation elongation factor 2, like
, ETS-related factor2
, LOW QUALITY PROTEIN: elongation factor 2
, CG2238 gene product from transcript CG2238-RD
, ELONGATION FACTOR 2
, elongation factor 2b
, eukaryotic translation elongation factor 2b