Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).
Vasseur, Domingues-Hamdi, Pakdaman, Galactéros, Baudin-Creuza: "Alpha haemoglobin-stabilising protein concentration in the red blood cells of patients with sickle cell anaemia with and without hydroxycarbamide treatment." in: British journal of haematology, Vol. 196, Issue 1, pp. 183-192, (2022) (PubMed).
Nasimuzzaman, Khandros, Wang, Kong, Zhao, Weiss, Rivella, Weiss, Persons: "Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia." in: American journal of hematology, Vol. 85, Issue 10, pp. 820-2, (2010) (PubMed).
Wang, Fang, Guo, Ren, Zhang: "Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice." in: Human gene therapy, Vol. 21, Issue 2, pp. 149-56, (2010) (PubMed).