The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011].
Calò, Licata, Bitto, Lo Cascio, Interdonato, Altavilla: "Role of AHR, AHRR and ARNT in response to dioxin-like PCBs in Spaurus aurata." in: Environmental science and pollution research international, Vol. 21, Issue 24, pp. 14226-31, (2014) (PubMed).