This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009].
Chen, Chen, Kawamura, Hoang, Yang, Wong, McBride, Repunte-Canonigo, Millhauser, Sanna: "Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function." in: iScience, Vol. 22, pp. 557-570, (2019) (PubMed).
Grayson, Allen, Billes, Williams, Smith, Grove: "Prenatal development of hypothalamic neuropeptide systems in the nonhuman primate." in: Neuroscience, Vol. 143, Issue 4, pp. 975-86, (2006) (PubMed).
Breen, Conwell, Wardlaw: "Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus." in: Brain research, Vol. 1032, Issue 1-2, pp. 141-8, (2005) (PubMed).
Aliases for AGRP 抗体
agouti related neuropeptide (AGRP) 抗体 agouti related neuropeptide (Agrp) 抗体 agouti-related protein pseudogene (LOC100352591) 抗体 AGRT 抗体 Agrt 抗体 ART 抗体 Art 抗体 ASIP2 抗体