(ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13))
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2008].
ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13) 蛋白 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (Adamts13) 蛋白 ADAM metallopeptidase with thrombospondin type 1 motif, 13 (adamts13) 蛋白 ADAM metallopeptidase with thrombospondin type 1 motif, 13 (Adamts13) 蛋白 ADAM metallopeptidase with thrombospondin type 1 motif 13 (Adamts13) 蛋白 ADAM-TS13 蛋白 ADAMTS-13 蛋白 ADAMTS13 蛋白 C9orf8 蛋白 Gm710 蛋白 vWF-CP 蛋白 VWFCP 蛋白