抗Mouse (Murine) PELI2 抗体:
抗Human PELI2 抗体:
抗Rat (Rattus) PELI2 抗体:
The functions of Pellino2 in the NLRP3 pathway are dependent on Pellino2 FHA and RING-like domains, with Pellino2 promoting the ubiquitination of NLRP3 during the priming phase of activation.
Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control.
Pellino-2 is a tissue-restricted component of a signaling pathway that couples the mouse pelle-like kinase/IL-1 receptor-associated kinase protein to IL-1- or lipopolysaccharide-dependent signaling.
A high-affinity Pellino2 e3 ubiquitin ligase binding domain is specific for phosphothreonine motifs.
interacts with TRAF6 (tumor necrosis factor receptor associated factor 6) and TAK1 (transforming growth factor-beta activated kinase 1); can activate the mitogen activated protein kinase pathway
Pellino2 interacts with kinase-active as well as kinase-inactive IRAK1 and IRAK4
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation (By similarity).
E3 ubiquitin-protein ligase pellino homolog 2
, protein pellino homolog 2
, pellino homolog 2