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The research reveals that among patients with essential hypertension treated with hypotensive drugs there are certain relationships between the rs5182 and rs5186 polymorphisms of the AGTR1 (显示 AGTR1 蛋白) gene, as well as between the rs1799998 polymorphism of the CYP11B2 gene and the volume of the carotid bodies.
Frequencies and distribution of genotype TT of CYP11B2 (C-344T) gene polymorphism among South African Black women, especially those without HIV infection, may prevent them from developing preeclampsia.
Aldosterone-producing adenomas (APAs) exhibit different patterns of CYP11B2 staining that vary from uniform to homogeneous. Approximately 30% of patients with unilateral hyperaldosteronism do not have an APA (显示 ENPEP 蛋白), but either have an increased number of CYP11B2 expressing micronodules or hyperplasia of the zona glomerulosa. [review]
In conclusion, our meta-analysis indicated that subjects with TT genotype might have higher risk of developing LVH in northern Han Chinese.
study demonstrated significant genetic interaction on Na intake with child obesity by salt-sensitive genes variations, NEDD4L (显示 NEDD4L 蛋白) and CYP11beta2
The combination of the V386A mutation with the variant CYP11B2 173(Arg) only slightly reduces the 18-hydroxylase and 18-oxidase activity, whereas the V386A mutation with the CYP11B2 173(Lys (显示 LYZ 蛋白)) variant almost abolishes the 18-hydroxylation and 18-oxidation. In both cases the 11-hydroxylase activity is not affected.
The AG genotype frequency of single nucleotide polymorphism rs542092383 was significantly associated with an increased risk of Essential Hypertension among northern Han Chinese.
the cellular distribution of CYP11B2, CYP11B1 (显示 CYP11B1 蛋白), CYP17A1 (显示 CYP17A1 蛋白) and KCNJ5 (显示 KCNJ5 蛋白) in adrenals from two familial hyperaldosteronism type 3 siblings, was examined.
Aging is associated with a pattern of decreased normal zona glomerulosa CYP11B2 expression.
CYP11B2 methylation was found in patients with aldosterone producing adenomas.
Aldosterone synthase knockout mouse shows odium-induced endothelial sodium channel up-regulation in vascular endothelium
Aldosterone synthase (CYP11B2) is a key regulator of fibrotic remodeling during atrial fibrillation.
Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1 (显示 NR5A1 蛋白)
Modest increase in aldosterone synthase (AS) expression makes blood pressure more sensitive to salt in mice, suggesting that genetically increased AS expression in humans may contribute to hypertension and cardiovascular complication with high-salt diets.
Fetal adrenal cells in primary culture respond to angiotensin-II (or synthetic ACTH (显示 POMC 蛋白)) by increasing aldosterone production and aldosterone synthase [P450c18/CYP11B2] activity.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
, aldosterone-synthesizing enzyme
, cytochrome P-450Aldo
, cytochrome P-450C18
, cytochrome P450 11B2, mitochondrial
, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2
, mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2
, steroid 11-beta-monooxygenase
, steroid 11-beta/18-hydroxylase
, steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
, cytochrome P450C11
, steroid 11-beta-hydroxylase
, Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase)
, Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)
, cytochrome P450 11B3, mitochondrial
, cytochrome P450, subfamily 11B, polypeptide 2
, cytochrome P450-Aldo-1
, cytochrome P450-Aldo-2
, mitochondrial cytochrome P450 11B2
, cytochrome P450, family 11, subfamily B, polypeptide 2