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MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenomas by down-regulating CYP11B2 expression.
Hybrid gene (8q24.3) due to unequal crossing (8q24.3) over cause Na over reabsorption in the distal nephron and volume expansion leading to Monogenic Hypertension Syndrome in children.
The research reveals that among patients with essential hypertension treated with hypotensive drugs there are certain relationships between the rs5182 and rs5186 polymorphisms of the AGTR1 gene, as well as between the rs1799998 polymorphism of the CYP11B2 gene and the volume of the carotid bodies.
Frequencies and distribution of genotype TT of CYP11B2 (C-344T) gene polymorphism among South African Black women, especially those without HIV infection, may prevent them from developing preeclampsia.
Aldosterone-producing adenomas (APAs) exhibit different patterns of CYP11B2 staining that vary from uniform to homogeneous. Approximately 30% of patients with unilateral hyperaldosteronism do not have an APA, but either have an increased number of CYP11B2 expressing micronodules or hyperplasia of the zona glomerulosa. [review]
In conclusion, our meta-analysis indicated that subjects with TT genotype might have higher risk of developing LVH in northern Han Chinese.
study demonstrated significant genetic interaction on Na intake with child obesity by salt-sensitive genes variations, NEDD4L and CYP11beta2
The combination of the V386A mutation with the variant CYP11B2 173(Arg) only slightly reduces the 18-hydroxylase and 18-oxidase activity, whereas the V386A mutation with the CYP11B2 173(Lys) variant almost abolishes the 18-hydroxylation and 18-oxidation. In both cases the 11-hydroxylase activity is not affected.
The AG genotype frequency of single nucleotide polymorphism rs542092383 was significantly associated with an increased risk of Essential Hypertension among northern Han Chinese.
the cellular distribution of CYP11B2, CYP11B1, CYP17A1 and KCNJ5 in adrenals from two familial hyperaldosteronism type 3 siblings, was examined.
Aging is associated with a pattern of decreased normal zona glomerulosa CYP11B2 expression.
CYP11B2 methylation was found in patients with aldosterone producing adenomas.
In European continental ancestry patients the C allele (CC or CT) at -344T/C SNP in the aldosterone synthase gene does not significantly influence clinical prognosis of chronic heart failure.
Data suggest that binding sites between CYP11B1/CYP11B2 and adrenodoxin/ferredoxin-1 exhibit electrostatic interactions at K370 in CYP11B1 and at K366 in CYP11B2 mutant R366K with D79 in adrenodoxin/ferredoxin-1. (CYP11B1 = cytochrome P450 family 11 subfamily B member 1; CYP11B2 = cytochrome P450 family 11 subfamily B member 2)
his study provided candidates for novel drug-like CYP11B2 inhibitors by molecular simulation methods for the hypertension treatment.
Suggest that there is lack of association between -344T/C polymorphism of CYP11B2 gene and coronary heart disease in Malaysian population.
Our study is aimed at evaluating the contribution of CYP11B2 promoter methylation to the risk of essential hypertension(EH). Our findings suggest that gene-environment interactions are associated with the pathogenesis and progression of EH
The present study revealed a strong synergistic effect of CYP11B2 C-344T and IC polymorphisms causing susceptibility to EHT and haplotype H1 (-344T-Conv-Lys173) as the risk-conferring factor for hypertension predisposition.
Deletions, duplications or chimeric CYP11B2/CYP11B1 gene is associated with 11beta-hydroxylase deficiency.
CYP11B2 T-344C single nucleotide polymorphism exhibited a strong association with the development of coronary artery disease in Taiwanese women.
Aldosterone synthase knockout mouse shows odium-induced endothelial sodium channel up-regulation in vascular endothelium
Aldosterone synthase (CYP11B2) is a key regulator of fibrotic remodeling during atrial fibrillation.
Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1
Modest increase in aldosterone synthase (AS) expression makes blood pressure more sensitive to salt in mice, suggesting that genetically increased AS expression in humans may contribute to hypertension and cardiovascular complication with high-salt diets.
Fetal adrenal cells in primary culture respond to angiotensin-II (or synthetic ACTH) by increasing aldosterone production and aldosterone synthase [P450c18/CYP11B2] activity.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
, aldosterone-synthesizing enzyme
, cytochrome P-450Aldo
, cytochrome P-450C18
, cytochrome P450 11B2, mitochondrial
, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2
, mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2
, steroid 11-beta-monooxygenase
, steroid 11-beta/18-hydroxylase
, steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
, cytochrome P450C11
, steroid 11-beta-hydroxylase
, Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase)
, Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)
, cytochrome P450 11B3, mitochondrial
, cytochrome P450, subfamily 11B, polypeptide 2
, cytochrome P450-Aldo-1
, cytochrome P450-Aldo-2
, mitochondrial cytochrome P450 11B2
, cytochrome P450, family 11, subfamily B, polypeptide 2