αC-conotoxin PrXA
产品编号 ABIN2566212
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for αC-conotoxin PrXA (ABIN2566212)
应用范围
Blocking Reagent (BR)
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序列
- AA sequence: Thr-Tyr-Gly-Ile-Tyr-Asp-Ala-Lys-Pro-Hyp -Phe-Ser-Cys13-Ala-Gly-Leu-Arg-Gly-Gly- Cys20-Val-Leu-Pro-Hyp-Asn-Leu-Arg-Hyp-Lys- Phe-Lys-Glu-NH2 Disulfide bonds: Cys13-Cys20
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产品特性
- Selective blocker of α1/β1/ε/δ and α1/β1/γ/δ nAChR subunits
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限制
- 仅限研究用
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储存条件
- -20 °C
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背景
- αC-Conotoxin PrXA (AlphaC-PrXA) was originally isolated from the venom of the fish-hunting Conus parius. αC-Conotoxin PrXA is a highly specific inhibitor of the neuromuscular nAChR. It potently antagonizes mouse muscle adult α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 = 3 nM). αC-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces (with higher affinity however for the α/δ subunit interface). The 3D structure of αC-Conotoxin PrXA is different from other conotoxins that target nAChR and it is most similar to Waglerin-1, a nAChR blocker isolated from a snake venom. αC-Conotoxin PrXA is a useful tool for investigating the structure and physiological role of nAChRs.
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分子量
- 3541.1 kDa
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