TMR-ShK
产品编号 ABIN2566196
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for TMR-ShK (ABIN2566196)
抗原
TMR-ShK (TMR-Stichodactyla toxin)
应用范围
Blocking Reagent (BR)
-
-
序列
- AA sequence: TMR-AEEAc-Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser -Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser -Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys -Thr-Cys32-Gly-Thr-Cys35-OH Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32
-
产品特性
- Fluorescent (red) Kv1.3 blockerPotassium channel blocker
-
-
-
限制
- 仅限研究用
-
-
-
储存条件
- -20 °C
-
有效期
- 2 months
-
-
- TMR-ShK (TMR-Stichodactyla toxin)
-
背景
- TMR-ShK peptide toxin is a fluorescent labeled version of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) with a Kd value of 11 pM, 16 pM, 312 pM and 165 pM, respectively. The fluorescent TMR-labeled ShK blocks Kv1.3 and Kv1.1 with Kd values of 52 pM and 397 pM, respectively. TMR-ShK can be used to identify lymphocytes expressing Kv1.3 channels such as effective memory T cells (TEM) in the case of autoimmune diseases (type 1 diabetes, mellitus or rheumatoid arthritis) which overexpress Kv1.3 channels. It can be used in confocal microscopy or FACS.
-
分子量
- 4611.7 kDa
抗原
-
You are here:
