Waglerin 1
Quick Overview for Waglerin 1 (ABIN1540138)
抗原
Waglerin 1
应用范围
Blocking Reagent (BR)
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原理
- Waglerin is a nAChR blocker
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序列
- Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys9-His-Pro-Pro-Cys13-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH(Disulfide bonds between Cys9-Cys13)
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限制
- 仅限研究用
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- Waglerin 1
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背景
- Waglerin 1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler's pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of muscle nicotinic acetylcholine receptors. Waglerin 1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin 1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin 1 are currently used in cosmetics to reduce wrinkles.
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分子量
- 2520 Da
抗原
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