Kaliotoxin-1
产品编号 ABIN1540091
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Kaliotoxin-1 (ABIN1540091)
抗原
Kaliotoxin-1
应用范围
Blocking Reagent (BR)
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原理
- Kaliotoxin-1 is a BK channel inhibitor
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序列
- Gly-Val-Glu-Ile-Asn-Val-Lys-Cys8-Ser-Gly-Ser-Pro-Gln-Cys14-Leu-Lys-Pro-Cys18-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn-Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OHDisulfid e bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35
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限制
- 仅限研究用
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- Kaliotoxin-1
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背景
- Kaliotoxin-1 has been isolated from the venom of the Scorpion Androctonus mauretanicus mauretanicus. Kaliotoxin-1 is a potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). This toxin also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Kaliotoxin-1 induces atransient period of fast flickering in the channel openings, followed by an almost complete blockage of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
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分子量
- 4150.37 Da
抗原
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