omega-Conotoxin MVIIA (omega conotoxin MVIIA)
产品编号 ABIN1540040
发货至:
中国
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Quick Overview for omega-Conotoxin MVIIA (omega conotoxin MVIIA) (ABIN1540040)
抗原
omega-Conotoxin MVIIA
应用范围
Blocking Reagent (BR)
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原理
- omega-Conotoxin MVIIA is a Cav2.2 channel blocker
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序列
- Cys1-Lys-Gly-Lys-Gly-Ala-Lys-Cys8-Ser-Arg-Leu-Met-Tyr-Asp-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys25
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限制
- 仅限研究用
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- omega-Conotoxin MVIIA
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背景
- Omega-Conotoxin MVIIA has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B). Omega-conotoxin MVIIA is available under the name Prialt by Neurex. It blocks acute pain in patients who no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium channels and disables nerves that transmit pain signals.
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分子量
- 2639.18 Da
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CAS-编号
- 107452-89-1
抗原
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