Apamin
产品编号 ABIN1540024
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for Apamin (ABIN1540024)
抗原
Apamin
应用范围
Blocking Reagent (BR)
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原理
- Apamin is a SK channel inhibitor
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序列
- Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2Disulfide bonds between Cys1-Cys11 and Cys3-Cys15
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限制
- 仅限研究用
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- Apamin
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背景
- Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. It inhibits three subtypes of SK channels (SK1, SK2, and SK3) with different affinity. Apamin most likely acts as a pore blocker, although residues both inside and outside of the pore region of the SK channels participate in0 apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.
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分子量
- 2027.34 Da
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CAS-编号
- 24345-16-2
抗原
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