omega-agatoxin IVA (omega-aga IVA or omega agatoxin IVA)
产品编号 ABIN1540020
发货至:
中国
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Quick Overview for omega-agatoxin IVA (omega-aga IVA or omega agatoxin IVA) (ABIN1540020)
抗原
omega-agatoxin IVA
应用范围
Blocking Reagent (BR)
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原理
- omega-agatoxin IVA is a blocker of Cav2.1 channel
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序列
- Lys-Lys-Lys-Cys4-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys12-Lys-Trp-Gly-Gly-Thr-Pro-Cys19-Cys20-Arg-Gly-Arg-Gly-Cys25-Ile-Cys27-Ser-Ile-Met-Gly-Thr-Asn-Cys34-Glu-Cys36-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH(Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34)
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限制
- 仅限研究用
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- omega-agatoxin IVA
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背景
- Omega-agatoxin IVA is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that omega-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for omega-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the alpha-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.
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分子量
- 5198.44 Da
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CAS-编号
- 145017-83-0
抗原
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