Piceatannol
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产品编号 ABIN1439971
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Piceatannol (ABIN1439971)
应用范围
Activation (Act)
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产品特性
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Activator of SIRT1
Inhibits NF-kB activation
Induces apoptosis
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限制
- 仅限研究用
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储存条件
- 4 °C
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背景
- Activator of human deacetylase SIRT1. Anti-inflammatory, immunomodulatory and antiproliferative agent that inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-kB activation and gene expression. Piceatannol is a resveratrol analog formed by the cytochrome P450-catalyzed hydroxylation of resveratrol. Piceatannol exhibits potent anticancer properties by inducing apoptosis in BJAB Burkitt-like lymphoma cells with an ED50 value of 25 µM. Piceatannol also exhibits anti-proliferative and anti-inflammatory effects by inhibiting the activity of a wide range of tyrosine and serine/threonine protein kinases and suppressing NF-kB activation through inhibition of IkBa kinase.
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CAS-编号
- 10083-24-6
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