SAHA (Vorinostat)
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Quick Overview for SAHA (Vorinostat) (ABIN1439970)
应用范围
Blocking Antibody (Inhibition)
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产品特性
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HDAC inhibitor
Cutaneous T-cell lymphoma treatment
In vitro and in vivo effects on latent HIV infected T-Cells
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限制
- 仅限研究用
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储存条件
- RT/4 °C
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背景
- SAHA (suberoylanilide hydroxamic acid, Vorinostat, Zolinza™) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. Sirt activator based on a dihydropyridine structural scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) is 1 uM for Sirt1, 25 uM for Sirt2, and 50 uM for Sirt3. The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. SAHA inhibits class I and class II HDACs at around 50 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 uM.
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分子量
- 264.3 kDa
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CAS-编号
- 149647-78-9
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