DMPO
Quick Overview for DMPO (ABIN1027923)
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原理
- Spin trapping reagent
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产品特性
- Nitrone adduct formation.
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纯度
- >98 %
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Chemical Name
- 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide, 5,5-Dimethyl-1-Pyrroline-N-Oxide, 3,4-dihydro-2,3-dimethyl-2H-pyrrole 1-oxide
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Formula
- C6H11NO
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Solubility
- Soluble to 100 mM in ethanol and to 100 mM in DMSO
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说明
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Source: Synthetic.
Appearance: Liquid -
限制
- 仅限研究用
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状态
- Solid
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注意事项
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes
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注意事项
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes
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储存条件
- -20 °C
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背景
- The formation of free radicals and other highly reactive oxygen species has been implicated in the pathogenesis of many disease states. The ability to identify these species is crucial, and spin trapping has accomplished this goal. DMPO (5,5-dimethyl-1-pyrroline N-oxide) is one of the least toxic to cells and animals, and possesses convenient pharmacokinetics (uptake, distribution, metabolism and excretion) in biological systems (2-6). Recent studies have determined that nitric oxide may substantially affect the quantitative determination of DMPO adducts, and therefore extra caution is required when studying generation of these species in the presence of nitric oxide or its radicals. DMPO adducts can be generated with protein and DNA radicals.
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分子量
- 113.16
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CAS-编号
- 3317-61-1
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