Epothilone B
产品编号 ABIN1027817
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Epothilone B (ABIN1027817)
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原理
- Microtubule stabilizer
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产品特性
- Microtubule stabilizing agent.
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纯度
- >98 %
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Chemical Name
- (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone
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Formula
- C27H41NO6S
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Solubility
- Soluble to 10 mM in DMSO
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说明
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Source: Synthetic.
Appearance: White Solid -
限制
- 仅限研究用
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状态
- Solid
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注意事项
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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注意事项
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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储存条件
- -20 °C
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背景
- Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin. Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site. Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis.
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分子量
- 507.68
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CAS-编号
- 152044-54-7
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