This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Aug 2008].
Mannan, Roussa, Kraus, Rickmann, Maenner, Nayernia, Krieglstein, Reis, Engel: "Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse." in: Neurogenetics, Vol. 5, Issue 4, pp. 229-38, (2005) (PubMed).
Ireton, Davis, van Hengel, Mariner, Barnes, Thoreson, Anastasiadis, Matrisian, Bundy, Sealy, Gilbert, van Roy, Reynolds: "A novel role for p120 catenin in E-cadherin function." in: The Journal of cell biology, Vol. 159, Issue 3, pp. 465-76, (2002) (PubMed).